The church of St. Ansanus was entirely rebuilt at the end of the 18th century by Milanese architect Antonio Dotti.
It features a single nave and keeps a series of interesting works of art, including a fresco by Giovanni di Pietro a.k.a. Lo Spagna portraying Madonna with Child and two saints, a surviving fragment of the bigger pictorial decoration at the “Lombards’ Chapel”, and a canvas by 17th-century painter Archita Ricci from Urbino, placed above the altar and portraying the Martyrdom of St. Ansanus.
The Crypt of St. Isaac is accessible from within the church; Syrian monk Isaac had reached Spoleto in the first half of the 6th century and became the first hermit on Monteluco. During the palaeochristian period, a church was obtained from the previously existing Roman temple, that would later become the crypt of the new church, built after the street level was raised. It features a nave and two side aisles, divided by spolia columns featuring 8th/9th-century capitals and covered by a groin vault. The crypt is decorated by very interesting 11th/12th-century frescoes that underwent detachment and restoration and were finally brought back in situ in 1971.
L’Umbria, Manuali per il Territorio, Spoleto, Roma 1978; A. Sansi, Degli edifici e dei frammenti storici delle antiche età di Spoleto,Foligno 1869